A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk.

Abstract

Mechanistic hypotheses suggest that vitamin D and the closely related parathyroid hormone (PTH) may be involved in prostate carcinogenesis. However, epidemiological evidence is lacking for PTH and inconsistent for vitamin D. Our objectives were to prospectively investigate the association between vitamin D status, vitamin D-related gene polymorphisms, PTH and prostate cancer risk. A total of 129 cases diagnosed within the Supplémentation en Vitamines et Minéraux Antioxydants cohort were included in a nested case-control study and matched to 167 controls (13 years of follow-up). 25-Hydroxyvitamin D (25(OH)D) and PTH concentrations were assessed from baseline plasma samples. Conditional logistic regression models were computed. Higher 25(OH)D concentration was associated with decreased risk of prostate cancer (ORQ4 v. Q1 0·30; 95 % CI 0·12, 0·77; P trend=0·007). PTH concentration was not associated with prostate cancer risk (P trend=0·4) neither did the studied vitamin D-related gene polymorphisms. In this prospective study, prostate cancer risk was inversely associated with 25(OH)D concentration but not with PTH concentration. These results bring a new contribution to the understanding of the relationship between vitamin D and prostate cancer, which deserves further investigation.

• Authors: Mélanie Deschasaux, Jean-Claude Souberbielle, Paule Latino-Martel, Angela Sutton, Nathalie Charnaux, Nathalie Druesne-Pecollo, Pilar Galan, Serge Hercberg, Sigrid Le Clerc, Emmanuelle Kesse-Guyot, Khaled Ezzedine, Mathilde Touvier
• Journal: The British journal of nutrition (Br J Nutr) Vol. 115 Issue 2 Pg. 305-14 (Jan 28 2016) ISSN: 1475-2662 [Electronic] England
• PMID: 26568368 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Parathyroid Hormone
• Placebos
• Receptors, Calcitriol
• Retinoid X Receptors
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adult
• Aged
• Case-Control Studies
• Double-Blind Method
• Genotype
• Humans
• Male
• Middle Aged
• Parathyroid Hormone (blood)
• Placebos
• Polymorphism, Single Nucleotide (genetics)
• Prospective Studies
• Prostatic Neoplasms (blood, genetics)
• Receptors, Calcitriol (genetics)
• Retinoid X Receptors (genetics)
• Risk Factors
• Vitamin D (analogs & derivatives, blood, genetics)