Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers.

Abstract

Cytochrome P450, family 2, subfamily W, polypeptide 1 (CYP2W1) is a newly identified monooxygenase enzyme that is expressed specifically in tumor tissues and during fetal life. Particularly, high expression of CYP2W1 was observed in up to 60% of colorectal cancers and its expression correlated with poor survival. CYP2W1 has been shown to metabolize various endogenous substrates including lysophospholipids and several procarcinogens, such as polycyclic aromatic hydrocarbon. The specific substrate for CYP2W1, however, is currently unknown. Due to its tumor-specific expression and its unique catalytic activities in colorectal cancers, CYP2W1 was deemed as an interesting target in colorectal cancer therapy. This review sought to summarize the current understanding of the CYP2W1 biology and biochemistry, its genetic polymorphisms and cancer risk, and its implication as a tumor-specific diagnostic and therapeutic target.

• Authors: Felicia Fei-Lei Chung, Chun Wai Mai, Pei Yuen Ng, Chee-Onn Leong
• Journal: Current cancer drug targets (Curr Cancer Drug Targets) Vol. 16 Issue 1 Pg. 71-8 ( 2016) ISSN: 1873-5576 [Electronic] Netherlands
• PMID: 26563883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cytochrome P-450 Enzyme System
• CYP2W1 protein, human
• Cytochrome P450 Family 2

Topics

• Colorectal Neoplasms (enzymology)
• Cytochrome P-450 Enzyme System (metabolism)
• Cytochrome P450 Family 2
• Humans