Abstract |
Accumulating evidence reveals that lipopolysaccharide (LPS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50mg/kg) for seven days and then treatmented (50mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus.
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Authors | Yanyan Fu, Hongzhi Liu, Chengjie Song, Fang Zhang, Yi Liu, Jian Wu, Xiangru Wen, Chen Liang, Kai Ma, Lei Li, Xunbao Zhang, Xiaoping Shao, Yafeng Sun, Yang Du, Yuanjian Song |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 29
Issue 2
Pg. 950-956
(Dec 2015)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 26558697
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015. Published by Elsevier B.V. |
Chemical References |
- Interleukin-6
- Lipopolysaccharides
- Nootropic Agents
- Xanthones
- interleukin-6, mouse
- mangiferin
- Heme Oxygenase-1
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Topics |
- Animals
- Body Weight
(drug effects)
- Heme Oxygenase-1
(biosynthesis, metabolism)
- Hippocampus
(drug effects, enzymology)
- Interleukin-6
(biosynthesis, genetics)
- Learning
(drug effects)
- Lipopolysaccharides
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Mice
- Nootropic Agents
(therapeutic use)
- Xanthones
(therapeutic use)
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