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Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice.

Abstract
Accumulating evidence reveals that lipopolysaccharide (LPS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50mg/kg) for seven days and then treatmented (50mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus.
AuthorsYanyan Fu, Hongzhi Liu, Chengjie Song, Fang Zhang, Yi Liu, Jian Wu, Xiangru Wen, Chen Liang, Kai Ma, Lei Li, Xunbao Zhang, Xiaoping Shao, Yafeng Sun, Yang Du, Yuanjian Song
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 29 Issue 2 Pg. 950-956 (Dec 2015) ISSN: 1878-1705 [Electronic] Netherlands
PMID26558697 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015. Published by Elsevier B.V.
Chemical References
  • Interleukin-6
  • Lipopolysaccharides
  • Nootropic Agents
  • Xanthones
  • interleukin-6, mouse
  • mangiferin
  • Heme Oxygenase-1
Topics
  • Animals
  • Body Weight (drug effects)
  • Heme Oxygenase-1 (biosynthesis, metabolism)
  • Hippocampus (drug effects, enzymology)
  • Interleukin-6 (biosynthesis, genetics)
  • Learning (drug effects)
  • Lipopolysaccharides
  • Male
  • Maze Learning (drug effects)
  • Memory (drug effects)
  • Mice
  • Nootropic Agents (therapeutic use)
  • Xanthones (therapeutic use)

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