Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula.

Abstract

OBJECTIVE:

Previous in vitro and in vivo studies indicated that catechins from the tea plant (Camellia sinensis) have a therapeutic effect on herpes simplex virus infections. The aim of this study was to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix, LLC, Evans, GA, USA) on recurrent herpes labialis.

STUDY DESIGN:

A double-blind, placebo-controlled, randomized trial with 40 participants, initially in two groups.

RESULTS:

Compared with the vehicle (100% glycerin USP, CVS Pharmacies, Inc., Woonsocket, RI, USA) group, AverTeaX applied topically six to eight times daily resulted in a significant reduction in clinical episode duration (median 4.5 days vs. 9 days; P = .003) and shortened blistering and ulceration stages within an episode from a median of 3 days to 1 day (P = .0003). Median quality-of-life scores, based on a multiquestion survey, showed significant differences between the groups with respect to duration of itching, from a median of 4 days to 1 day (P = .0021), and duration until symptom free, from a median of 8 days to 4 days (P = .0016). Significant differences were not found for median scores for itching, pain, burning, swelling, bleeding, and stress. Adverse effects were not reported.

CONCLUSION:

AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance.

• Authors: Man Zhao, Rong Zheng, Jinyan Jiang, Douglas Dickinson, Baiping Fu, Tin-Chun Chu, Lee Hwang Lee, Henna Pearl, Stephen Hsu
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 120 Issue 6 Pg. 717-24 (Dec 2015) ISSN: 2212-4411 [Electronic] United States
• PMID: 26548726 (Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Antioxidants
• AverTeaX
• Flavonoids
• Tea
• Catechin
• epigallocatechin gallate

Topics

• Administration, Topical
• Adult
• Antioxidants (administration & dosage, therapeutic use)
• Catechin (administration & dosage, analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Flavonoids (administration & dosage, therapeutic use)
• Herpes Labialis (drug therapy)
• Humans
• Male
• Middle Aged
• Quality of Life
• Recurrence
• Surveys and Questionnaires
• Tea
• Treatment Outcome