Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis.

Abstract

Experiments on random-bred albino mice showed that activation α7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-α (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. After combined administration of anti-TNF-α antibodies and anabasine, an additive effect was observed.

• Authors: P F Zabrodskii, M S Gromov, V V Maslyakov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 6 Pg. 740-2 (Oct 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 26525714 (Publication Type: Journal Article)

Chemical References

• Antibodies
• Cytokines
• Inflammation Mediators
• Tumor Necrosis Factor-alpha
• alpha7 Nicotinic Acetylcholine Receptor
• Anabasine

Topics

• Anabasine (pharmacology)
• Animals
• Antibodies (pharmacology)
• Cytokines (blood)
• Disease Progression
• Female
• Inflammation Mediators (blood)
• Male
• Mice
• Sepsis (blood, mortality, pathology)
• Time Factors
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, immunology)
• alpha7 Nicotinic Acetylcholine Receptor (agonists)