[A Case of HER-2 Positive Advanced Gastric Cancer Responding to Capecitabine＋Cisplatin＋Trastuzumab Chemotherapy].

Abstract

A 67-year-old woman was referred to our hospital for type 1 gastric cancer. We diagnosed the patient with advanced gastric cancer (tub2>por, HER2-positive), and the clinical findings were T4aN1M1 (lung), Stage Ⅳ. The patient had cancer cachexia. As first-line chemotherapy, a regimen consisting of capecitabine (X) (1,600 mg/m2/day, days 1-14), cisplatin (P) (60 mg/m2/day, day 1), and trastuzumab (H) (8 mg/kg/day>6 mg/kg/day, day 1) was administered every 3 weeks and repeated 6 times. After receiving 6 courses, the patient's general condition and cancer cachexia symptoms improved. The size of the primary lesion significantly decreased, and lung metastasis was not visible on a PET scan. Simultaneously, a new 0-Ⅱc tumor was detected in the cardia, and a biopsy revealed a malignant lymphoma. Total gastrectomy and D2 lymph node dissection without splenectomy were performed. The final diagnosis was T4aN0M0. After treatment, the tumor was histologically evaluated as Grade 1b, and the remnant cancer cells were found to be HER2-negative (loss of HER2). The patient has been alive for 5 months and is receiving adjuvant chemotherapy comprising capecitabine and trastuzumab. Following chemotherapy containing trastuzumab, the patient with cachexia who was diagnosed with unresectable HER2-positive advanced gastric cancer showed improvement in the cachexia symptoms and the disappearance of lung metastasis.

• Authors: Kenki Segami, Tsutomu Sato, Taiichi Kawabe, Shigeya Hayashi, Yosuke Makuuchi, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 10 Pg. 1295-7 (Oct 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26489577 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Capecitabine
• ERBB2 protein, human
• Receptor, ErbB-2
• Trastuzumab
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cachexia (etiology)
• Capecitabine (administration & dosage)
• Cisplatin (administration & dosage)
• Female
• Gastrectomy
• Humans
• Neoadjuvant Therapy
• Receptor, ErbB-2 (analysis)
• Stomach Neoplasms (complications, drug therapy, pathology, surgery)
• Trastuzumab (administration & dosage)
• Treatment Outcome