Abstract | BACKGROUND AND AIM: SUBJECTS AND METHODS: Twenty Japanese patients with T2DM were enrolled. Baseline data were obtained on the first day and dapagliflozin (5 mg) was administered at 6:00 on the second day. Glucose excursions were assessed by continuous glucose monitoring and urine samples were collected every hour during the daytime (7:00 to 15:00) on both days. RTg was estimated from the regression line of the scatter plot of the hourly mean glucose concentrations. RESULTS: After a single dose of dapagliflozin, RTg decreased from 121.5 to 6.1 mg/dl in the young adult group and from 151.0 mg/dl to -15.8 mg/dl in the older group. After dapagliflozin, the slope of the regression line was significantly steeper in the young adult group. CONCLUSION:
Dapagliflozin was more effective in young patients because they showed a larger response of urinary glucose excretion.
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Authors | Yuta Nakamura, Yoshio Nagai, Yuko Terashima, Ami Nishine, Satoshi Ishii, Hiroyuki Kato, Akio Ohta, Yasushi Tanaka |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 16
Issue 17
Pg. 2553-9
( 2015)
ISSN: 1744-7666 [Electronic] England |
PMID | 26479189
(Publication Type: Journal Article)
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Chemical References |
- Benzhydryl Compounds
- Glucosides
- Hypoglycemic Agents
- Sodium-Glucose Transporter 2 Inhibitors
- dapagliflozin
- Glucose
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Topics |
- Adult
- Benzhydryl Compounds
(therapeutic use)
- Diabetes Mellitus, Type 2
(drug therapy, physiopathology, urine)
- Female
- Glucose
(metabolism)
- Glucosides
(therapeutic use)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Kidney
(drug effects, physiopathology)
- Male
- Middle Aged
- Sodium-Glucose Transporter 2 Inhibitors
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