Abstract |
Applying sol gel based coatings to orthopedic metallic implant materials can significantly improve their properties and lifespan in vivo. For this work, niobium ( Nb2O5) and titanium (TiO2) oxides were prepared via solution processing in order to determine the effect of atomic arrangement (amorphous/crystalline) on bioactivity. Thermal evaluation on the synthesized materials identified an endotherm for Nb2O5 at 75 °C with 40% weight loss below 400 °C, and minimal weight loss between 400 and 850 °C. Regarding TiO2 an endotherm was present at 92 °C with 25% weight loss below 400 °C, and 4% between 400 and 850 °C. Phase evolution was determined using High Temperature X-ray Diffraction (HT-XRD) where amorphous-Nb2O5 (450 °C), hexagonal-Nb2O5 (525 °C), orthorhombic-Nb2O5 (650 °C), amorphous-TiO2 (275 °C) and tetragonal TiO2 (500 °C) structures were produced. Simulated body fluid (SBF) testing was conducted over 1, 7 and 30 days and resulted in positive chemical and morphological changes for crystalline Nb2O5 (525 °C) and TiO2 (500 °C) after 30 days of incubation. Rod-like CaP deposits were observed on the surfaces using Scanning Electron Microscopy (FE-SEM) and Grazing Incidence-X-ray Diffraction (GI-XRD) shows that the deposits were X-ray amorphous. Cell viability was higher with the TiO2 (122%) samples when compared to the growing cell population while Nb2O5 samples exhibited a range of viability (64-105%), partially dependent on materials atomic structure.
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Authors | D Pradhan, A W Wren, S T Misture, N P Mellott |
Journal | Materials science & engineering. C, Materials for biological applications
(Mater Sci Eng C Mater Biol Appl)
Vol. 58
Pg. 918-26
(Jan 01 2016)
ISSN: 1873-0191 [Electronic] Netherlands |
PMID | 26478387
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Coated Materials, Biocompatible
- Oxides
- Niobium
- titanium dioxide
- Titanium
- niobium pentoxide
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Topics |
- Animals
- Cell Line
- Cell Survival
(drug effects)
- Coated Materials, Biocompatible
(chemistry, toxicity)
- Mice
- Microscopy, Electron, Scanning
- Niobium
(chemistry, toxicity)
- Oxides
(chemistry, toxicity)
- Prostheses and Implants
- Spectrum Analysis, Raman
- Surface Properties
- Thermogravimetry
- Titanium
(chemistry, toxicity)
- X-Ray Diffraction
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