Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius.

Abstract

Utilization of chemical pesticide to control monogenean diseases is often restricted in many countries due to the development of pesticide resistance and concerns of chemical residues and environmental contamination. Thus, the use of antiparasitic agents from plants has been explored as a possible way for controlling monogenean infections. Extracts from Cinnamomum cassia were investigated under in vivo conditions against Dactylogyrus intermedius in goldfish. The two bioactive compounds, cinnamaldehyde and cinnamic acid, were identified using nuclear magnetic resonance and electrospray ionization mass spectrometry. The 48 h median effective concentrations (EC(50)) for these compounds against D. intermedius were 0·57 and 6·32 mg L(-1), respectively. The LD(50) of cinnamaldehyde and cinnamic acid were 13·34 and 59·66 mg L(-1) to goldfish in 48 h acute toxicity tests, respectively. These data confirm that cinnamaldehyde is effective against D. intermedius, and the cinnamaldehyde exhibits potential for the development of a candidate antiparasitic agent.

• Authors: Fei Ling, Chao Jiang, Guanglu Liu, Mingshuang Li, Gaoxue Wang
• Journal: Parasitology (Parasitology) Vol. 142 Issue 14 Pg. 1744-50 (Dec 2015) ISSN: 1469-8161 [Electronic] England
• PMID: 26442478 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Cinnamates
• Oils, Volatile
• cinnamic acid
• Acrolein
• cinnamaldehyde

Topics

• Acrolein (analogs & derivatives, pharmacology, therapeutic use, toxicity)
• Animals
• Anthelmintics (pharmacology, therapeutic use, toxicity)
• Biological Assay
• Cinnamates (pharmacology, therapeutic use, toxicity)
• Cinnamomum aromaticum (chemistry)
• Fish Diseases (drug therapy, parasitology)
• Gills (parasitology)
• Goldfish (parasitology)
• Lethal Dose 50
• Magnetic Resonance Spectroscopy
• Microscopy, Electron, Scanning
• Oils, Volatile (chemistry)
• Plant Bark (chemistry)
• Platyhelminths (drug effects, ultrastructure)
• Spectrometry, Mass, Electrospray Ionization
• Trematode Infections (drug therapy, parasitology, veterinary)