Tegafur gimeracil oter combined with oxaliplatin for advanced colorectal cancer.

Abstract

OBJECTIVE:

To analyze the therapeutic actions of tegafur gimeracil oteracil combined with oxaliplatin for treating patients with advanced colorectal cancer, and its effects on the K-ras gene mutation and the CK20 mRNA.

PATIENTS AND METHODS:

Forty-one patients with advanced colorectal cancer from our hospital, from October 2013 to October 2014, were enrolled in this study. After obtaining consent from the hospital Ethics Committee and the patients as well as their relatives, all 41 patients were divided into two groups. The control group, which consisted of 20 cases, were treated with capecitabine combined with oxaliplatin. The study group, which comprised of 21 cases, were treated with tegafur gimeracil oteracil combined with oxaliplatin. Both groups were followed-up after six months to evaluate the treatment outcomes.

RESULTS:

The survival rate in the observation group was higher than that in the control group. The progression-free survival time (PFS) in the observation group was longer than that in the control group. The objective response rate (ORR) and disease control rate (DCR) were higher for the observation group. The differences had statistical significance (p < 0.05). The proportion of K-ras gene mutation in the observation group was substantially superior to that in the control group. The positive expression rate of CK 20 mRNA in the observation group was significantly lower than that in the control group. The differences had statistical significance (p < 0.05). The incidence of adverse reaction in the observation group was lower than that of the control group, and the differences had statistical significance (p < 0.05).

CONCLUSIONS:

Tegafur/gimeracil/oteracil combined with oxaliplatin therapy had better treatment outcomes than capecitabine combined oxaliplatin for advanced colorectal cancer. This maybe related to K-ras gene mutation and the reduction of CK20 mRNA expression.

• Authors: Z-H Yang, J Ren, L-J Yi, J-H Zheng, H Wei
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 19 Issue 18 Pg. 3391-6 (Sep 2015) ISSN: 2284-0729 [Electronic] Italy
• PMID: 26439033 (Publication Type: Journal Article)

Chemical References

• Organoplatinum Compounds
• Pyridines
• Oxaliplatin
• Tegafur
• gimeracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Colorectal Neoplasms (drug therapy, mortality, pathology)
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, therapeutic use)
• Oxaliplatin
• Pyridines (administration & dosage, therapeutic use)
• Tegafur (administration & dosage, therapeutic use)