Abstract | PURPOSE: METHOD: Clinical data were reviewed for hospitalized patients diagnosed with isolated ON combined with chronic hepatitis B (CHB-ON) in the Chinese People's Liberation Army General Hospital. The ON diagnosis was confirmed following the criteria of the Optic Neuritis Treatment Trial (ONTT) group. The diagnostic criteria for CHB was serological positivity for hepatitis B surface antigen ( HBsAg) for more than 6 months. Other infectious conditions that might lead to bias were excluded. RESULTS: A total of 13 patients (6 female and 7 male, 23 involved eyes) diagnosed with CHB-ON were selected. A total of 12/13 patients presented as atypical ON: 10/13 of the patients exhibited simultaneous or early sequential bilateral eye involvement; 11/13 involved eyes in the acute phase presented with pronounced optic disc edema; and 11/13 patients exhibited corticosteroid resistant. A total of 12/23 affected eyes suffered severe vision loss (<20/200) at the end of the follow-up period, which averaged 13.7 (4-31) months. None of the patients progressed to multiple sclerosis (MS) or neuromyelitis optica (NMO). All blood samples were negative for serological aquaporin 4-antibody using the cell-based assay. CONCLUSIONS:
|
Authors | Shuo Zhao, Tingjun Chen, Chunxia Peng, Huanfen Zhou, Hongyang Li, Dehui Huang, Quangang Xu, Shihui Wei |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 358
Issue 1-2
Pg. 207-12
(Nov 15 2015)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 26363926
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Aquaporin 4
- Autoantibodies
|
Topics |
- Adult
- Aquaporin 4
(immunology)
- Autoantibodies
(blood)
- Disease Progression
- Female
- Hepatitis B, Chronic
(blood, complications)
- Humans
- Male
- Middle Aged
- Optic Neuritis
(blood, complications)
- Retrospective Studies
|