Abstract |
Rats selected for their low performance baselines in an active avoidance shuttle box task were given various doses of R-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A), S- amphetamine or piracetam. BL-3912A at 1 mg/kg IP had no significant behavioral effects, while 5 and 10 mg/kg significantly increased the number of avoidance responses without affecting responses during the intertrial interval (ITI). Statistically reliable effects on behavior were not observed following 20 mg/kg of BL-3912A. S- Amphetamine at 0.5 and 1 mg/kg IP also facilitated avoidance responding, but could be differentiated from BL-3912A in that the S- amphetamine significantly increased shuttles during the ITI. S- Amphetamine at 0.1 mg/kg was not effective, while 2 mg/kg increased ITI activity. Piracetam (50 or 200 mg/kg) had no significant effects on avoidance or shuttles during ITI. Using an electric shock titration procedure, BL-3912A at 10 and 20 mg/kg IP had no significant effect on reaction thresholds. Animals receiving 100 mg/kg of p-chlorophenylalanine po for 3 days and tested 2 days later showed hyperalgesia to the electric shock. In summary, BL-3912A facilitated shuttle box avoidance responding of rats with low performance baselines. Behavioral facilitation occurred without concomitant increases in noncontingent activity or apparent changes in reactivity to electric footshock.
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Authors | H A Tilson, J H Chamberlain, J A Gylys |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 6
Issue 6
Pg. 627-30
(Jun 1977)
ISSN: 0091-3057 [Print] United States |
PMID | 263545
(Publication Type: Journal Article)
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Chemical References |
- Amphetamines
- Hallucinogens
- dimoxamine
- 2,5-Dimethoxy-4-Methylamphetamine
- Amphetamine
- Piracetam
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Topics |
- 2,5-Dimethoxy-4-Methylamphetamine
(analogs & derivatives, pharmacology)
- Amphetamine
(pharmacology)
- Amphetamines
(pharmacology)
- Animals
- Avoidance Learning
(drug effects)
- Electroshock
- Hallucinogens
(pharmacology)
- Male
- Piracetam
(pharmacology)
- Rats
- Rats, Inbred Strains
- Sensory Thresholds
(drug effects)
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