Amphetamine (Amfetamine)

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1873 relevant articles (57 outcomes, 192 trials/studies) found for this Drug

Description: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Also Known As:

Amfetamine; l Amphetamine; Amphetamine Sulfate; Amphetamine Sulfate (2:1); Centramina; Fenamine; Miquel Brand of Amfetamine Sulfate; Mydrial; Phenamine; Thyramine; levo-Amphetamine; Sulfate, Amphetamine; levo Amphetamine; Desoxynorephedrin; Levoamphetamine; Phenopromin; l-Amphetamine; Benzeneethanamine, alpha-methyl-, (+-)-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

Dextroamphetamine: 641

Experts

1.	Spencer, Thomas J: 6 articles (05/2006 - 08/2005)
2.	Biederman, Joseph: 6 articles (05/2006 - 04/2005)
3.	Palermo-Neto, J: 2 articles (09/2008 - 08/2000)
4.	Sutton, R L: 2 articles (06/2008 - 01/2000)
5.	Hovda, D A: 2 articles (06/2008 - 01/2000)
6.	Kovatchev, Boris: 2 articles (02/2008 - 09/2006)
7.	Cox, Daniel J: 2 articles (02/2008 - 09/2006)
8.	Merkel, R Lawrence: 2 articles (02/2008 - 09/2006)
9.	Moore, Melissa: 2 articles (02/2008 - 09/2006)
10.	Ersche, Karen D: 2 articles (09/2007 - 05/2006)

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 05/10/2006 - "Psychostimulants, including amphetamine, act as antihyperkinetic agents in humans with hyperkinetic disorder such as attention-deficit hyperactivity disorder and are known to be effective in enhancing attention-related processes; however, the underlying mechanisms have not been adequately addressed" 07/01/2007 - "OBJECTIVE: A review of amphetamine treatment for attention-deficit/hyperactivity disorder (ADHD) was conducted, to obtain information on the long-term neurological consequences of this therapy" 10/01/2005 - "Quantitation of R-(-)- and S-(+)-amphetamine in hair and blood by gas chromatography-mass spectrometry: an application to compliance monitoring in adult-attention deficit hyperactivity disorder treatment." 10/01/2005 - "Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates." 02/01/2004 - "Amphetamine salt compound treatment for adults with attention deficit hyperactivity disorder." Order ALL the reference details at left...
2.	Schizophrenia (Dementia Praecox) 12/01/2006 - "In this study, rats were tested in behavioural paradigms relevant to schizophrenia during withdrawal from two different administration schedules of amphetamine (Amph)" 05/01/2006 - "In conclusion, the results of this study further document the involvement of GLU transmission in regulating the effect of amphetamine-induced DA release, and provide additional support to the hypothesis that the dysregulation of DA function revealed by the amphetamine challenge in schizophrenia might stem from a deficit in GLU transmission." 09/17/2004 - "In this study, three common behavioral models of schizophrenia were tested, i.e., latent inhibition (LI), prepulse inhibition of the startle response (PPI) and hyperlocomotion under amphetamine" 11/15/2003 - "The aim of these studies was to examine whether amphetamine-induced sensitization in rats could be used as an animal model to study the basis of certain abnormalities seen in schizophrenia" 05/15/2003 - "Previous studies showed that rats with neonatal excitotoxic damage of the ventral hippocampus (VH), used as an animal model of this disorder, display in young adulthood a variety of abnormalities reminiscent of schizophrenia, including hyperactivity to stressful stimuli and amphetamine" Order ALL the reference details at left...
3.	Seizures (Seizure) 10/26/1998 - "Further studies to determine whether neuronal damage is the result of or the cause of amphetamine-induced seizures are necessary." 05/01/2007 - "CONCLUSION: The results show that khat stimulates locomotor and stereotypic behavioural activity and can induce seizures; results similar to those observed with amphetamine analogs." 05/01/2004 - "The formulation also significantly antagonised the amphetamine induced hyper-locomotor activity (500, 750 mg/kg, po) and protected mice against tonic convulsions induced by maximal electroshock (500, 750 mg/kg, po)" 06/01/2003 - "Amphetamine rarely induces seizures at therapeutic doses, but seizure may occur after the first dose" 12/06/2002 - "Analysis of illicit amphetamine seizures by capillary zone electrophoresis." Order ALL the reference details at left...
4.	Catalepsy 03/01/2005 - "KK13 is thus the first NT[8-13] analogue described to date that demonstrates inhibition of amphetamine-induced hyperlocomotion without inducing catalepsy while maintaining day-to-day hypothermic potency." 02/01/2005 - "The results revealed that the extract caused a decrease in spontaneous activity and induced catalepsy in mice up to 240 min. The extract significantly protected the mice against amphetamine-induced toxicity and decreased the conditioned response in rats, in a dose-related manner" 02/01/2005 - "roots on locomotor activity, catalepsy test, amphetamine-induced toxicity and active-avoidance test were studied" 05/01/2003 - "On the basis of the results of catalepsy and amphetamine-induced stereotypy, the compounds demonstrated an inhibitory effect on dopaminergic behaviors" 01/01/1997 - "In rats, the NNC-compounds blocked conditioned avoidance responding and attenuated the discriminative stimulus effects of amphetamine, but failed to induce catalepsy" Order ALL the reference details at left...
5.	Brain Injuries (Brain Injury) 09/21/2006 - "Axonal plasticity is associated with motor recovery following amphetamine treatment combined with rehabilitation after brain injury in the adult rat." 01/01/2000 - "Measurements of oxidative metabolic capacity following the ablation of rat sensorimotor cortex and the administration of amphetamine were examined to determine their effects on the metabolic dysfunction that follows brain injury" 09/07/1998 - "Amphetamine administration improves neurochemical outcome of lateral fluid percussion brain injury in the rat." 02/01/1996 - "Amphetamine in recovery from brain injury." 08/01/1992 - "The beneficial effects of amphetamine after brain injury may be limited to restoration of sensorimotor ability and not to cognitive functions such as memory." Order ALL the reference details at left...

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Related Therapies and Procedures

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4.	Aftercare (After-Treatment)
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