[The immunization of white rats with a covalent conjugate of sidnofen and serum albumin suppresses chronic ethanol consumption].

Abstract

The influence of white rats of alcohol abuse formation of immunization by covalent conjugates of serum albumin with psychostimulant sydnophen was investigated. Immunization by conjugates where the molar sydnophen: protein ratio was 18:1-33: 1 results in significant depression of 15% ethanol consumption (in the condition of free choice between water and ethanol solution).

• Authors: I P Ashmarin, R A Danilova, M D Mashkovskiĭ, M F Obukhova, Sh K Sagimbaeva
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 108 Issue 12 Pg. 695-7 (Dec 1989) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Immunizatsiia belykh krys kovalentnym kon''iugatom sidnofena s serumal'buminom podavliaet khronicheskoe potreblenie étanola.
• PMID: 2634442 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidepressive Agents
• Haptens
• Oxadiazoles
• Serum Albumin
• Sydnones
• sydnophen

Topics

• Alcoholism (immunology, therapy)
• Animals
• Antidepressive Agents (immunology, therapeutic use)
• Drug Evaluation, Preclinical
• Haptens (immunology, therapeutic use)
• Immunization (methods)
• Male
• Oxadiazoles (immunology)
• Rats
• Serum Albumin (immunology, therapeutic use)
• Sydnones (immunology, therapeutic use)
• Time Factors