Changes in NSILA-S in response to somatotropin administration and hypophysectomy.

Abstract

The effects on the serum levels of NSILA-S of the administration of human GH (hGH) or of hypophysectomy have been studied. hGH given im (5 mg daily for 3 days) raised the NSILA-S levels of three GH-deficient subjects into the normal range. Significant elevations of NSILA-S were also seen in three normal subjects given im GH. In the same groups of three normal and three GH-deficient subjects, 5 mg hGH administered iv induced an elevation of NSILA-S within 15-60 min. Hypophysectomy in three acromegalics and one subject with a chromophobe adenoma was followed by significant falls of serum NSILA-S. These studies provide further evidence of the dependence of NSILA-S levels on GH.

• Authors: R C Franklin, G C Rennie, H G Burger, D P Cameron
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 47 Issue 1 Pg. 91-6 (Jul 1978) ISSN: 0021-972X [Print] United States
• PMID: 263296 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nonsuppressible Insulin-Like Activity
• Growth Hormone

Topics

• Acromegaly (physiopathology)
• Adult
• Growth Hormone (deficiency)
• Humans
• Hypophysectomy
• Hypopituitarism (physiopathology)
• Middle Aged
• Nonsuppressible Insulin-Like Activity (metabolism)
• Reference Values