We present a series of 35 cases of digital
myxoid cyst in which we specifically looked for transepidermal migration of
mucin. We found it in 57.14% of the cases (20/35). In these cases, there were collections of
mucin in an intraepidermal
bulla as well as multiple intercellular droplets of
mucin in many cases. All cases of perforating
mucinosis described so far in the literature have presented clinically as papular eruptions. We therefore conclude that (1) perforating
mucinoses do not exclusively present as multiple papules but also occur as single lesions; (2) transepidermal elimination of
mucin is a very common but not yet reported phenomenon in digital
myxoid cysts; (3) the morphological findings suggest real transepidermal migration of the
mucin instead of exposure of the
mucin to the surface via ulceration.