Abstract |
Genome-wide association studies have identified many lipid-associated loci primarily in European and Asian populations. In view of the differences between ethnic groups in terms of the frequency and impact of these variants, our objective was to evaluate the relationships between eight lipid-associated variants (considered individually and in combination) and fasting serum triglyceride, total cholesterol, HDL- and LDL-cholesterol levels in an Algerian population sample (ISOR study, n = 751). Three SNPs (in SORT1, CETP and GCKR) were individually associated with lipid level variations. Moreover, the risk allele scores for total cholesterol, triglyceride and LDL-C levels (encompassing between three and six SNPs) were associated with their corresponding lipid traits. Our study is the first to show that some of the lipid-associated loci in European populations are associated with lipid traits in Algerians. Although our results will have to be confirmed in other North African populations, this study contributes to a better understanding of genetic susceptibility to lipid traits in Algeria.
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Authors | Djabaria Naïma Meroufel, Sounnia Mediene-Benchekor, Sarah Aïcha Lardjam-Hetraf, Hadjira Ouhaïbi-Djellouli, Houssam Boulenouar, Imane Hamani-Medjaoui, Xavier Hermant, Nadhira Saïdi-Mehtar, Philippe Amouyel, Leïla Houti, Aline Meirhaeghe, Louisa Goumidi |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 8
Issue 6
Pg. 7358-63
( 2015)
ISSN: 1936-2625 [Electronic] United States |
PMID | 26261636
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- APOA1 protein, human
- Adaptor Proteins, Signal Transducing
- Adaptor Proteins, Vesicular Transport
- Apolipoprotein A-I
- Apolipoproteins E
- Biomarkers
- CETP protein, human
- Cholesterol Ester Transfer Proteins
- GCKR protein, human
- LDLR protein, human
- Lipids
- Receptors, LDL
- LPL protein, human
- Lipoprotein Lipase
- sortilin
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Topics |
- Adaptor Proteins, Signal Transducing
(genetics)
- Adaptor Proteins, Vesicular Transport
(genetics)
- Algeria
- Apolipoprotein A-I
(genetics)
- Apolipoproteins E
(genetics)
- Biomarkers
(blood)
- Black People
(genetics)
- Cholesterol Ester Transfer Proteins
(genetics)
- Gene Frequency
- Genetic Association Studies
- Genotype
- Humans
- Lipids
(blood)
- Lipoprotein Lipase
(genetics)
- Phenotype
- Polymorphism, Single Nucleotide
- Receptors, LDL
(genetics)
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