The authors study the effects of three
acids, one with four
carbon atoms,
dihydroxymaleic acid, the two others with three
carbon considered atoms,
ketomalonic acid and
tartronic acid. A first study considered the effects of these products on experimental
lithiasis induced by
oxalic acid,
glyoxylic acid and
ethylene-glycol.
Dihydroxymaleic acid.
Monohydrate calcium oxalate stones can be easily induced in the male rat, with in 24 hours, by an
intraperitoneal injection of
oxalic acid, at the rate of 8 mg per 100 g of
body weight. If 25 mg of
dihydroxymaleic acid are injected simultaneously via the intraperitoneal route, to a rat weighing 150 g, the
lithiasis observed after 24 hours is just as severe. Experimental
monohydrate calcium oxalate lithiasis is also induced by
intraperitoneal injection of 8 to 9 mg of
glyoxylic acid in a 100 mg rat.
Dihydroxymaleic acid, injected at the same time as
glyoxylic acid, also via the intraperitoneal route, at the rate of 50 mg for a rat weighing 150 g, results in total suppression of the
lithiasis.
Dihydroxymaleic acid also prevents
lithiasis induced by the absorption by the rat, for several weeks, of a 1%
ethylene-glycol solution if it is mixed to this
solution at the rate of 5 mg per ml. A 12%
ethylene-glycol solution given to the rat at the rate of 0.55 ml for 100 g of
body weight induces the next day a
comatose state and a diffuse parenchymatous
monohydrate calcium oxalate lithiasis:
coma and
lithiasis are prevented by the simultaneous absorption of
dihydroxymaleic acid at the rate of 65 to 70 mg. The
ketomalonic acid.(ABSTRACT TRUNCATED AT 250 WORDS)