Prognostic factors affecting survival in metastatic soft tissue sarcoma: an analysis of 110 patients.

Abstract

BACKGROUND:

Data on treatment outcome and prognostic factors in patients with metastatic soft tissue sarcoma (STS) are limited in the literature.

METHODS:

A total of 119 patients with metastatic STS treated between June 2003 and December 2012 were analyzed for treatment outcome and prognostic factors.

RESULTS:

Median age was 37 years (range 2-72 years) with a male to female ratio of 1.5:1. Most common histologic subtypes were synovial sarcoma (36 %) and leiomyosarcoma (16 %). Median tumor size was 12 cm (range 1.6-30 cm). Twenty-four (20 %) patients were treated with multimodality therapy and 80 % patients received systemic chemotherapy alone. At a median follow-up of 10 months (range 1-66 months), the 2-year EFS and OS were 10 and 19 %, respectively, with a median EFS and OS of 6 and 10 months, respectively. Univariate analysis identified albumin ≤4 g/dl (p = 0.001), histologic subtypes other than synovial sarcoma (p = 0.02), non-extremity tumors (p = 0.03) and single modality treatment (p = 0.03) as factors predicting poor EFS; however, for OS, hemoglobin ≤10 g/dl (p = 0.02), tumor size >10 cm (p = 0.01) and single modality treatment (p = 0.04) were identified as poor prognostic factors. Multivariate analysis identified only serum albumin ≤4 g/dl (p = 0.002, HR 0.47, 95 % CI 0.29-0.75) associated with poor EFS; however, for OS, hemoglobin ≤10 g/dl (p = 0.009, HR 0.49, 95 % CI 0.29-0.83), tumor size >10 cm (p = 0.003, HR 2.11, 95 % CI 1.28-3.47) and single modality treatment (p = 0.01, HR 0.47, 95 % CI 0.25-0.86) emerged as poor prognostic factors.

CONCLUSIONS:

Serum albumin, tumor size, hemoglobin and treatment modality affect survival in metastatic STS.

• Authors: N Iqbal, N K Shukla, S V S Deo, S Agarwala, D N Sharma, M C Sharma, S Bakhshi
• Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (Clin Transl Oncol) Vol. 18 Issue 3 Pg. 310-6 (Mar 2016) ISSN: 1699-3055 [Electronic] Italy
• PMID: 26243399 (Publication Type: Journal Article)

Chemical References

• Hemoglobins
• Serum Albumin

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Hemoglobins
• Humans
• Infant
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Metastasis
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Sarcoma (mortality, pathology, therapy)
• Serum Albumin
• Soft Tissue Neoplasms (mortality, pathology, therapy)
• Treatment Outcome
• Young Adult