Abstract | OBJECTIVE: Gene expression dysregulation in the brain has been associated with bipolar disorder through candidate gene and microarray expression studies, but questions remain about isoform-specific dysregulation and the role of noncoding RNAs whose importance in the brain has been suggested recently but not yet characterized for bipolar disorder. METHOD: The authors used RNA sequencing, a powerful technique that captures the complexity of gene expression, in postmortem tissue from the anterior cingulate cortex from 13 bipolar disorder case subjects and 13 matched comparison subjects. Differential expression was computed, and a global pattern of downregulation was detected, with 10 transcripts significant at a false discovery rate ≤5%. Importantly, all 10 genes were also replicated in an independent RNA sequencing data set (N=61) from the anterior cingulate cortex. RESULTS: CONCLUSIONS:
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Authors | Cristiana Cruceanu, Powell Patrick Cheng Tan, Sanja Rogic, Juan Pablo Lopez, Susana Gabriela Torres-Platas, Carolina O Gigek, Martin Alda, Guy A Rouleau, Paul Pavlidis, Gustavo Turecki |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 172
Issue 11
Pg. 1131-40
(Nov 01 2015)
ISSN: 1535-7228 [Electronic] United States |
PMID | 26238605
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimanic Agents
- CHRM2 protein, human
- Lithium Compounds
- RNA, Messenger
- RXFP1 protein, human
- Receptor, Muscarinic M2
- Receptors, G-Protein-Coupled
- Receptors, Peptide
- Receptors, Somatostatin
- SSTR2 protein, human
- Carbamazepine
- Valproic Acid
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Topics |
- Adult
- Antimanic Agents
(pharmacology)
- Bipolar Disorder
(genetics, metabolism)
- Carbamazepine
(pharmacology)
- Case-Control Studies
- Cell Line
- Female
- Gene Expression Profiling
- Gene Expression Regulation
(drug effects, genetics)
- Gyrus Cinguli
(metabolism)
- Humans
- In Vitro Techniques
- Lithium Compounds
(pharmacology)
- Male
- Middle Aged
- Neural Stem Cells
(drug effects, metabolism)
- RNA, Messenger
(drug effects, metabolism)
- Real-Time Polymerase Chain Reaction
- Receptor, Muscarinic M2
(drug effects, genetics)
- Receptors, G-Protein-Coupled
(drug effects, genetics)
- Receptors, Peptide
(drug effects, genetics)
- Receptors, Somatostatin
(drug effects, genetics)
- Sequence Analysis, RNA
- Valproic Acid
(pharmacology)
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