Abstract | OBJECTIVE: To describe changes in venous blood gas analytes during isoflurane anesthesia in black-tailed prairie dogs (Cynomys ludovicianus). DESIGN: Prospective study. ANIMALS: 16 black-tailed prairie dogs. PROCEDURES: Black-tailed prairie dogs were placed in an anesthesia chamber for induction of general anesthesia, which was maintained with isoflurane in oxygen delivered via mask. Immediately following anesthetic induction, a venous blood sample was obtained from the medial saphenous vein; a second venous blood sample was obtained just prior to anesthetic gas shutoff. An evaluation of venous blood gas analytes was performed on each sample. General linear mixed models with repeated measures were used for data analyses. RESULTS: Median anesthetic time was 90 minutes (range, 60 to 111 minutes). A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride ion, BUN, and creatinine concentrations. A decrease in Po2, mean blood pH, and anion gap was observed from induction of anesthesia to completion. No significant differences during anesthesia were observed in mean base excess or blood bicarbonate, sodium, potassium, calcium, magnesium, blood glucose, lactate, and total CO2 concentrations. No complications occurred during or after anesthesia for any animal. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Sara M Gardhouse, David Eshar, Nora Bello, Diane Mason |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 247
Issue 4
Pg. 404-8
(Aug 15 2015)
ISSN: 1943-569X [Electronic] United States |
PMID | 26225612
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Inhalation
- Isoflurane
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Topics |
- Anesthesia, General
(veterinary)
- Anesthetics, Inhalation
(administration & dosage, blood, pharmacokinetics)
- Animals
- Animals, Zoo
(physiology)
- Blood Gas Analysis
(veterinary)
- Female
- Isoflurane
(administration & dosage, blood, pharmacokinetics)
- Male
- Prospective Studies
- Sciuridae
(physiology)
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