Treatment of neonatal fungal infective endocarditis with recombinant tissue plasminogen: activator in a low birth weight infant case report and review of the literature.

Abstract

With advances in medical sciences, an increase in survival rates of low birth weight; increased incidence in use of catheter and antibiotics, and total parenteral nutrition are reported, therefore, the rate of fungal infections in late and very late onset neonatal sepsis have increased. Although fungal endocarditis rarely occur in newborns, it has a high morbidity and mortality. Antifungal therapy is often insufficient in cases who develop fungal endocarditis and surgical treatment is not preferred due to its difficulty and high mortality. Herein, fungal endocarditis in a preterm newborn treated with single-dose recombinant tissue plasminogen activator in addition to antifungal therapy is presented and relevant literature has been reviewed. The vegetation completely disappeared following treatment and no complication was observed.

• Authors: Aslan Babayigit, Burcu Cebeci, Gokhan Buyukkale, Seda Yılmaz Semerci, Helen Bornaun, Kazim Oztarhan, Muge Gokce, Merih Cetinkaya
• Journal: Mycoses (Mycoses) Vol. 58 Issue 10 Pg. 578-81 (Oct 2015) ISSN: 1439-0507 [Electronic] Germany
• PMID: 26214750 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © 2015 Blackwell Verlag GmbH.

Chemical References

• Antifungal Agents
• Fibrinolytic Agents
• Tissue Plasminogen Activator

Topics

• Antifungal Agents (therapeutic use)
• Brain (microbiology)
• Candida albicans (growth & development, isolation & purification)
• Candidiasis, Invasive (drug therapy, microbiology)
• Echocardiography
• Endocarditis (drug therapy, microbiology)
• Escherichia coli (isolation & purification)
• Female
• Fibrinolytic Agents (therapeutic use)
• Heart (microbiology)
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (drug therapy, microbiology)
• Infant, Very Low Birth Weight
• Sepsis (drug therapy, microbiology)
• Tissue Plasminogen Activator (therapeutic use)