Prognostic evaluation of mucin-5AC expression in intrahepatic cholangiocarcinoma, mass-forming type, following hepatectomy.

Abstract

AIM:

This study aimed to investigate the clinicopathological predictors of survival in patients with intrahepatic cholangiocarcinoma, mass-forming type (ICC-MF), following curative intent hepatectomy.

METHODS:

Clinical characteristics and outcomes were analyzed in a series of 42 patients who underwent curative hepatectomy for ICC-MF between February 1987 and December 2012. The relationship between immunohistochemical expression profiles of mucin (MUC) core proteins (MUC2, MUC5AC, and MUC6) and surgical outcomes was examined.

RESULTS:

The overall median follow-up period was 2.6 years (0.2-17.9). Bile duct reconstruction (p = 0.017), lymph node metastasis (p = 0.049), maximal mass diameter ≥5.0 cm (p = 0.002), and MUC5AC expression (p = 0.003) were identified as significant adverse predictors of overall survival by univariate analysis. Bile duct reconstruction (p = 0.048), maximal mass diameter ≥5.0 cm (p = 0.002), and MUC5AC expression (p = 0.005) were found to be independent predictors of poor prognosis by multivariate analysis. Maximal mass diameter ≥5.0 cm (p = 0.011) was found to be an independent predictor for the tumor recurrence. There was a strong correlation between MUC5AC expression and lymph node metastasis (p = 0.021). MUC6 expression was more frequent in patients with concurrent MUC5AC expression (p = 0.019).

CONCLUSIONS:

MUC5AC expression was significantly related to long-term prognosis and aggressive tumor development, and may be a useful prognostic marker.

• Authors: T Abe, H Amano, F Shimamoto, M Hattori, S Kuroda, T Kobayashi, H Tashiro, H Ohdan
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 41 Issue 11 Pg. 1515-21 (Nov 2015) ISSN: 1532-2157 [Electronic] England
• PMID: 26210654 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Mucin 5AC

Topics

• Aged
• Aged, 80 and over
• Bile Duct Neoplasms (diagnosis, metabolism, surgery)
• Bile Ducts, Intrahepatic
• Biomarkers, Tumor (biosynthesis)
• Cholangiocarcinoma (diagnosis, metabolism, surgery)
• Female
• Follow-Up Studies
• Hepatectomy
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Mucin 5AC (biosynthesis)
• Neoplasm Staging
• Postoperative Period
• Prognosis
• Retrospective Studies
• Time Factors
• Tomography, X-Ray Computed