Deficiencies in essential
trace elements are associated with impaired immunity in
tuberculosis infection. However, the
trace element concentrations in the serum of Korean patients with
tuberculosis have not yet been investigated. This study aimed to compare the serum
trace element concentrations of Korean adult patients with
tuberculosis with noninfected controls and to assess the impact of serum
trace element concentration on clinical outcome after antituberculosis treatment. The serum concentrations of four
trace elements in 141 consecutively recruited patients with
tuberculosis and 79 controls were analyzed by inductively coupled plasma-mass spectrometry. Demographic characteristics were also analyzed. Serum
cobalt and
copper concentrations were significantly higher in patients with
tuberculosis compared with controls, while
zinc and
selenium concentrations were significantly lower (p < 0.01). Moreover, serum
selenium and
zinc concentrations were positively correlated (ρ = 0.41, p < 0.05). A high serum
copper concentration was associated with a worse clinical outcome, as assessed after one month of antituberculosis
therapy. Specifically, culture-positive patients had higher serum
copper concentrations than culture-negative patients (p < 0.05). Patients with
tuberculosis had altered serum
trace element concentrations. Further research is needed to elucidate the roles of individual
trace elements and to determine their clinical impact on patients with
tuberculosis.