The weight of obesity on the human immune response to vaccination.

Abstract

Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI) ≥ 30 kg/m(2). The immune system is adversely affected by obesity, and these "immune consequences" raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.

• Authors: Scott D Painter, Inna G Ovsyannikova, Gregory A Poland
• Journal: Vaccine (Vaccine) Vol. 33 Issue 36 Pg. 4422-9 (Aug 26 2015) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 26163925 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Vaccines

Topics

• Humans
• Obesity
• Vaccines (administration & dosage, immunology)