Abstract | INTRODUCTION: METHODS: RESULTS: Overall, 203 patients were included in the study. The agreement between the different tests ranged from 64% to 77%: FS vs. HA, 72%; FS vs. APRI, 74%; FS vs. HS, 77%; and FS vs. FIB-4, 64%. After excluding patients with chronic hepatitis B or C and elevated CDT, 153 patients remained for studying the hepatotoxicity of HAART. A significant correlation of FS with the duration of medication intake was observed for PIs (P = 0.026; r = 0.18). NRTI and NNRTI therapy duration did not correlate with FS. CONCLUSIONS: The agreement between FS and other tests ranged from 64% to 77%. A significant correlation was found between liver stiffness and the duration of therapy with PIs, which underlines the known hepatotoxicity of this substance group. FUNDING: Heinz-Ansmann Foundation.
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Authors | Abdurrahman Sagir, Birgit Glaubach, Kurtulus Sahin, Dirk Graf, Andreas Erhardt, Mark Oette, Dieter Häussinger |
Journal | Infectious diseases and therapy
(Infect Dis Ther)
Vol. 4
Issue 3
Pg. 355-64
(Sep 2015)
ISSN: 2193-8229 [Print] New Zealand |
PMID | 26143457
(Publication Type: Journal Article)
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