Abstract | PURPOSE: Allogeneic haematopoietic stem cell transplantation (HSCT) is a proven treatment for patients with haematological malignancies. In this retrospective analysis, the impact of donor matching on outcome of unrelated HSCT was analysed in patients transplanted at the University of Leipzig. METHODS: RESULTS: After a median follow-up of 49 months, outcome at 5 years in recipients of HLA-identical grafts was comparable to that of patients transplanted from HLA-incompatible donors with an overall survival (OS) of 52 % (95 % CI 43-61) versus 48 % (95 % CI 34-63), respectively (p = 0.48). Results were also comparable for event-free survival at 5 years [47 % (95 % CI 38-56) vs. 39 % (95 % CI 25-54); p = 0.44], relapse incidence (RI) [29 % (95 % CI 20-38) vs. 41 (95 % CI 25-57); p = 0.22] and non-relapse mortality [24 % (95 % CI 16-33) vs. 20 % (95 % CI 8-33); p = 0.84] in the matched versus mismatched groups. Incidence of acute and chronic GvHD was similar in both groups. Advanced disease (p = 0.02) and low-resolution typing (p = 0.04) are risk factors for OS and RI in univariate and multivariate analysis. CONCLUSIONS: Donors with one antigen mismatch are an acceptable option for patients with malignant disease for whom no fully matched donor is available.
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Authors | A Rockstroh, H K Al-Ali, T Lange, W Pönisch, R Krahl, M Cross, G Behre, D Niederwieser, C Pfrepper |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 141
Issue 12
Pg. 2193-203
(Dec 2015)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 26129640
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Female
- Follow-Up Studies
- Graft vs Host Disease
(epidemiology, immunology, mortality)
- HLA Antigens
(immunology)
- Hematologic Neoplasms
(immunology, mortality, therapy)
- Hematopoietic Stem Cell Transplantation
(mortality)
- Histocompatibility
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(immunology, mortality, therapy)
- Neoplasm Staging
- Prognosis
- Retrospective Studies
- Survival Rate
- Transplantation Conditioning
- Transplantation, Homologous
- Unrelated Donors
- Young Adult
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