Abstract | OBJECTIVE: DESIGN: This is a prospective observational study of GH treatment in two girls with matUPD(14) during 2 years, and spontaneous growth in another matUPD(14) girl of similar age. PATIENTS: Three girls (patient A, B and C, aged 8·9, 11·4 and 12·7 years, respectively) with matUPD(14) were included in this study. MEASUREMENTS: Patients A and B were treated with GH during 2 years. Patient C was not treated with GH, as she was diagnosed at an age at which she attained near-final height. Main outcome measures included height, weight, body proportions, IGF-1, bone age, and DXA scan for body composition. RESULTS: In both treated girls, a considerable increase in height (from -2·3SD and -1·2SD to -1·2SD and -0·6SD, respectively) and IGF-1 levels (from +0·1SD and -1·4SD to +1·3SD and +0·9SD, respectively) and, in patient A, a decrease in weight (+1·2 SD to -0·7SD), and improved body composition (fat percentage from 51·5% to 45·4%) were found. Both experienced improved muscle strength. CONCLUSIONS: GH treatment in matUPD(14) cases can show beneficial effects on growth and body composition if started in time. Larger, international studies to determine detailed effectivity and side effects are suggested.
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Authors | Susanne E Stalman, Gerdine A Kamp, Yvonne M C Hendriks, Raoul C M Hennekam, Joost Rotteveel |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 83
Issue 5
Pg. 671-6
(Nov 2015)
ISSN: 1365-2265 [Electronic] England |
PMID | 26119964
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adolescent
- Body Composition
(drug effects)
- Child
- Child Development
(drug effects)
- Chromosomes, Human, Pair 14
- Female
- Growth Hormone
(pharmacology, therapeutic use)
- Humans
- Prospective Studies
- Uniparental Disomy
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