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Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion.

AuthorsAlexander M Menzies, Iwei Yeh, Thomas Botton, Boris C Bastian, Richard A Scolyer, Georgina V Long
JournalPigment cell & melanoma research (Pigment Cell Melanoma Res) Vol. 28 Issue 5 Pg. 607-10 (Sep 2015) ISSN: 1755-148X [Electronic] England
PMID26072686 (Publication Type: Case Reports, Letter, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • BRAF-KIAA1549 fusion protein, human
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Oncogene Proteins, Fusion
  • PPFIBP2 protein, human
  • Pyridones
  • Pyrimidinones
  • trametinib
  • pembrolizumab
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • MAP Kinase Kinase Kinases
Topics
  • Aged
  • Antibodies, Monoclonal, Humanized (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Brain Neoplasms (diagnosis, pathology, secondary)
  • Carrier Proteins (metabolism)
  • DNA Mutational Analysis
  • Disease Progression
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • MAP Kinase Kinase Kinases (antagonists & inhibitors)
  • Magnetic Resonance Imaging
  • Male
  • Melanoma (drug therapy, genetics)
  • Membrane Proteins (metabolism)
  • Middle Aged
  • Neoplasm Metastasis
  • Oncogene Proteins, Fusion (metabolism)
  • Proto-Oncogene Proteins B-raf (metabolism)
  • Pyridones (therapeutic use)
  • Pyrimidinones (therapeutic use)
  • Skin Neoplasms (drug therapy, genetics)
  • Treatment Outcome

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