Abstract | BACKGROUND: METHODS: This was a retrospective cohort study of 48 eyes from 24 patients with dry eye treated with 2% rebamipide ophthalmic suspension. Dry eye-related symptom score, tear film break-up time (TBUT), fluorescein ocular surface staining score (FOS) and the Schirmer test were used to collect the data from patients at baseline, and at 2, 4, 8, and 12 week visits. To determine the relevant factors, multiple regression analyses were then performed. RESULTS: Mean dry eye-related symptom score showed a significant improvement from the baseline (14.5 points) at 2, 4, 8 and 12 weeks (9.80, 7.04, 7.04 and 7.83 points, corrected P value < 0.001, respectively). Median FOS showed a significant improvement from the baseline (3.0 points) at 2, 4, 8 and 12 weeks (2.0, 2.0, 1.0 and 1.0 points, corrected P value < 0.001, respectively). TBUT and Schirmer test values were not significantly improved after the treatment. For ocular symptoms, three parameters ( foreign body sensation, dry eye sensation and ocular discomfort) showed significant improvements at all visits. The multiple regression analyses showed that the fluorescein conjunctiva staining score was significantly correlated with the changes of dry eye-related symptom score at 12 weeks (P value = 0.017) and dry eye-related symptom score was significantly correlated with independent variables for the changes of FOS at 12 weeks (P value = 0.0097). CONCLUSIONS:
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Authors | Kaori Ueda, Wataru Matsumiya, Keiko Otsuka, Yoshifumi Maeda, Takayuki Nagai, Makoto Nakamura |
Journal | BMC ophthalmology
(BMC Ophthalmol)
Vol. 15
Pg. 58
(Jun 06 2015)
ISSN: 1471-2415 [Electronic] England |
PMID | 26048396
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Enzyme Inhibitors
- Fluorescent Dyes
- Ophthalmic Solutions
- Quinolones
- Suspensions
- rebamipide
- Alanine
- Fluorescein
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Topics |
- Aged
- Alanine
(administration & dosage, analogs & derivatives)
- Antioxidants
(administration & dosage)
- Cornea
(physiology)
- Dry Eye Syndromes
(drug therapy, physiopathology)
- Enzyme Inhibitors
(administration & dosage)
- Female
- Fluorescein
- Fluorescent Dyes
- Humans
- Male
- Ophthalmic Solutions
- Quinolones
(administration & dosage)
- Retrospective Studies
- Suspensions
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