Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant.

Abstract

Hb Luxembourg [alpha 24(B5)Tyr----His] was found in association with mild hemolytic anemia and increased indirect bilirubinemia in a family originating from the Netherlands. The slight instability of this variant may be the consequence of an indirect effect of the substitution on the alpha 1 beta 1 contact since position alpha 24 (B5) is internal and in contact with several residues involved in this interface.

• Authors: P Groff, F Galacteros, G Kalmes, Y Blouquit, H Wajcman
• Journal: Hemoglobin (Hemoglobin) Vol. 13 Issue 5 Pg. 429-36 ( 1989) ISSN: 0363-0269 [Print] England
• PMID: 2599879 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amino Acids
• Hemoglobins, Abnormal
• Peptide Fragments
• hemoglobin Luxembourg
• Tyrosine
• Histidine
• Trypsin

Topics

• Adolescent
• Adult
• Amino Acids (analysis)
• Chromatography, High Pressure Liquid
• Female
• Genetic Variation
• Hemoglobins, Abnormal (genetics, isolation & purification)
• Histidine
• Humans
• Male
• Middle Aged
• Peptide Fragments (isolation & purification)
• Trypsin
• Tyrosine