Abstract | BACKGROUND: CASE: A 34-year-old woman with chronic hepatitis C started peritoneal dialysis because of progressive renal disease 2 years after peripheral blood stem cell transplantation for aplastic anaemia. The regimen was a single 6-h dwell of 2L glucose dialysate. Considering that her HCV genotype was 2a and that she was a candidate for cadaveric kidney transplant, we decided to treat her with PEG-IFN alpha-2a monotherapy 1 year after the beginning of peritoneal dialysis. We adopted a dose escalation strategy to minimize the total amount of PEG-IFN administration, thereby reducing the risk of adverse effects. Her HCV- RNA disappeared at the 17th week and sustained virus response was achieved thereafter. Only minor side effects were observed including flu-like symptoms and mild anaemia, and residual renal function remained stable during the treatment of 48 weeks (renal Kt/V; from 1.28 to 1.26). CONCLUSION: PEG-IFN monotherapy with dose modification may be a safe and effective treatment for HCV infection in patients undergoing peritoneal dialysis.
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Authors | Imari Mimura, Yoshitaka Ishibashi, Ryosuke Tateishi, Shinya Kaname, Toshiro Fujita |
Journal | NDT plus
(NDT Plus)
Vol. 1
Issue 4
Pg. 233-5
(Aug 2008)
ISSN: 1753-0784 [Print] England |
PMID | 25983890
(Publication Type: Case Reports)
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