RNA G-Quadruplex: The New Potential Targets for Therapy.

Abstract

Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA Gquadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.

• Authors: Shi-Ke Wang, Yue Wu, Tian-Miao Ou
• Journal: Current topics in medicinal chemistry (Curr Top Med Chem) Vol. 15 Issue 19 Pg. 1947-56 ( 2015) ISSN: 1873-4294 [Electronic] United Arab Emirates
• PMID: 25980415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• RNA

Topics

• Animals
• G-Quadruplexes (drug effects)
• Humans
• RNA (chemistry, drug effects, metabolism)