Alpha chemokines in Crohn's disease.

Abstract

Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 and its ligand chemokines, as monokine induced by interferon (IFN)-γ (MIG), interferon-γ inducible protein (IP-10) and IFN-inducible T cell-α chemoattractant (I-TAC), are strongly overexpressed both in the intestinal mucosa of mice with experimental colitis, and in patients with Crohn's disease (CD) in lymphocytes, in macrophages and in epithelial cells. IFN-γ induces CXCR3 and its chemokines expression in epithelial intestinal cells; these chemokines are important for the recruitment of granulocytes and mononuclear cells, thus for the maintenance of inflammation in CD. Serum IP-10 levels might reflect CD disease activity, and it may be a marker for the responsiveness of patients to treatments. However other studies are needed to document the use of IP-10 in clinical setting. Attempts are currently underway to inhibit CXCR3 or its chemokines in CD as a possible therapy of CD.

• Authors: A Devito
• Journal: La Clinica terapeutica (Clin Ter) Vol. 166 Issue 2 Pg. e114-7 ( 2015) ISSN: 1972-6007 [Electronic] Italy
• PMID: 25945443 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• CXCL10 protein, human
• CXCR3 protein, human
• Chemokine CXCL10
• Receptors, CXCR3
• Interferon-gamma

Topics

• Animals
• Biomarkers (blood)
• Chemokine CXCL10 (blood)
• Crohn Disease (metabolism)
• Epithelial Cells (metabolism)
• Humans
• Interferon-gamma (physiology)
• Intestinal Mucosa (metabolism)
• Mice
• Receptors, CXCR3 (metabolism)