Marfan Sartan: a randomized, double-blind, placebo-controlled trial.

Abstract

AIMS:

To evaluate the benefit of adding Losartan to baseline therapy in patients with Marfan syndrome (MFS).

METHODS AND RESULTS:

A double-blind, randomized, multi-centre, placebo-controlled, add on trial comparing Losartan (50 mg when <50 kg, 100 mg otherwise) vs. placebo in patients with MFS according to Ghent criteria, age >10 years old, and receiving standard therapy. 303 patients, mean age 29.9 years old, were randomized. The two groups were similar at baseline, 86% receiving β-blocker therapy. The median follow-up was 3.5 years. The evolution of aortic diameter at the level of the sinuses of Valsalva was not modified by the adjunction of Losartan, with a mean increase in aortic diameter at the level of the sinuses of Valsalva of 0.44 mm/year (s.e. = 0.07) (-0.043 z/year, s.e. = 0.04) in patients receiving Losartan and 0.51 mm/year (s.e. = 0.06) (-0.01 z/year, s.e. = 0.03) in those receiving placebo (P = 0.36 for the comparison on slopes in millimeter per year and P = 0.69 for the comparison on slopes on z-scores). Patients receiving Losartan had a slight but significant decrease in systolic and diastolic blood pressure throughout the study (5 mmHg). During the study period, aortic surgery was performed in 28 patients (15 Losartan, 13 placebo), death occurred in 3 patients [0 Losartan, 3 placebo, sudden death (1) suicide (1) oesophagus cancer (1)].

CONCLUSION:

Losartan was able to decrease blood pressure in patients with MFS but not to limit aortic dilatation during a 3-year period in patients >10 years old. β-Blocker therapy alone should therefore remain the standard first line therapy in these patients.

• Authors: Olivier Milleron, Florence Arnoult, Jacques Ropers, Philippe Aegerter, Delphine Detaint, Gabriel Delorme, David Attias, Florence Tubach, Sophie Dupuis-Girod, Henry Plauchu, Martine Barthelet, Francois Sassolas, Nicolas Pangaud, Sophie Naudion, Julie Thomas-Chabaneix, Yves Dulac, Thomas Edouard, Jean-Eric Wolf, Laurence Faivre, Sylvie Odent, Adeline Basquin, Gilbert Habib, Patrick Collignon, Catherine Boileau, Guillaume Jondeau
• Journal: European heart journal (Eur Heart J) Vol. 36 Issue 32 Pg. 2160-6 (Aug 21 2015) ISSN: 1522-9645 [Electronic] England
• PMID: 25935877 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: [email protected].

Chemical References

• Adrenergic beta-Antagonists
• Angiotensin II Type 1 Receptor Blockers
• Losartan

Topics

• Adolescent
• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Aged
• Angiotensin II Type 1 Receptor Blockers (administration & dosage)
• Aortic Diseases (complications, drug therapy, mortality)
• Blood Pressure (drug effects)
• Dilatation, Pathologic (complications, drug therapy, mortality)
• Double-Blind Method
• Drug Administration Schedule
• Female
• Heart Rate (drug effects)
• Humans
• Hypertension (prevention & control)
• Losartan (administration & dosage)
• Male
• Marfan Syndrome (complications, mortality)
• Middle Aged
• Prospective Studies
• Young Adult