Concurrent and cross-season protection of inactivated influenza vaccine against A(H1N1)pdm09 illness among young children: 2012-2013 case-control evaluation of influenza vaccine effectiveness.

Abstract

In 2012-2013, we examined 1729 laboratory-confirmed A(H1N1)pdm09 influenza cases matched 1:1 with healthy controls and estimated influenza vaccine effectiveness (VE) for trivalent inactivated influenza vaccine (IIV3) to be 67% (95% confidence interval=58-74%) for ages 8 months to 6 years old. Among children aged 8-35 months old, VE for fully vaccinated children (73%, 60-81%) was significantly higher than VE for partially vaccinated children (55%, 33-70%). Significant cross-season protection from prior IIV3 was noted, including VE of 31% (8-48%) from IIV3 received in 2010-2011 against influenza illness in 2012--2013 without subsequent boosting doses.

• Authors: Chuanxi Fu, Jianxiong Xu, Jinyan Lin, Ming Wang, Kuibiao Li, Jing Ge, Mark G Thompson
• Journal: Vaccine (Vaccine) Vol. 33 Issue 25 Pg. 2917-21 (Jun 09 2015) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 25921713 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Published by Elsevier Ltd.

Chemical References

• Influenza Vaccines
• Vaccines, Inactivated

Topics

• Case-Control Studies
• Child
• Child, Preschool
• China
• Cross Protection
• Female
• Humans
• Infant
• Influenza A Virus, H1N1 Subtype (immunology)
• Influenza Vaccines (immunology)
• Influenza, Human (prevention & control, virology)
• Male
• Seasons
• Vaccination
• Vaccine Potency
• Vaccines, Inactivated (immunology)