Bioactive metabolites from Cnidoscolus souzae and Acmella pilosa.

Abstract

The bioassay-guided purification of the ethanol extracts of Acmella pilosa and Cnidoscolus souzae, two plants of the native flora of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain, resulted in the identification of rosmarinic acid (1) and caffeic acid (2) as the bioactive metabolites from A. pilosa, and of 7-deoxynimbidiol (4) as the major bioactive metabolite from C. souzae. Metabolites 1, 2, and 4 proved to be responsible for the antioxidant activity originally detected in the corresponding organic crude extracts; 7-deoxynimbidiol (4) showed good analgesic and anti-inflammatory activities, inhibiting the pain induced by PGE2 and reducing the edema induced by carrageenan, respectively.

• Authors: Hiatzy E Zapata-Estrella, Azeret D M Sánchez-Pardenilla, Karlina García-Sosa, Fabiola Escalante-Erosa, Fátima de Campos-Buzzi, Nara Lins Meira-Quintão, Valdir Cechinel-Filho, Luis M Peña-Rodríguez
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 9 Pg. 1319-21 (Sep 2014) ISSN: 1934-578X [Print] United States
• PMID: 25918802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Plant Extracts

Topics

• Analgesics (administration & dosage, chemistry, metabolism, pharmacology)
• Animals
• Anti-Inflammatory Agents (chemistry, metabolism, pharmacology)
• Asteraceae (chemistry, metabolism)
• Edema (drug therapy, immunology)
• Euphorbiaceae (chemistry, metabolism)
• Humans
• Male
• Mice
• Plant Extracts (chemistry, metabolism, pharmacology)