Risk factors and incidence for lipid abnormalities in kidney transplant patients.

Abstract

BACKGROUND:

Lipid abnormalities (LA) are related to an increased risk for cardiovascular diseases in kidney transplantation patients.

PATIENTS AND METHODS:

Multivariable logistic regression models were used to estimate the risk of LA associated with potential risk factors, including immunosuppressant use, patient background characteristics, and laboratory data.

RESULTS:

In total, 386 patients who were undergoing kidney transplantation were included in the study. Statins were prescribed to 43% of patients. The LA composite outcome was defined as statin use and/or low density lipoprotein cholesterol level ≥120 mg/dL, and 229 patients (59.3%) developed LA as a result. LA was significantly related to everolimus, corticosteroid, age, and estimated glomerular filtration ratio in the multiple logistic regression analysis. The odds ratios were 2.264, 3.119, 1.186, and 0.870, respectively. Mycophenolate mofetil, mizoribine, azathioprine, cyclosporine (CYA), tacrolimus, proteinuria, body mass index, and male sex were not related to LA.

DISCUSSION:

CYA influenced lipid metabolism but was not related to LA in our study. The mean post transplantation period was 8.4 years, and the CYA dose decreased over time. The CYA blood concentration was 70.0 ng/mL, which is relatively low, but it decreased the susceptibility to LA. Serum lipid levels were well controlled by statins, and the estimated glomerular filtration rate was maintained stably.

CONCLUSIONS:

Everolimus and corticosteroid use, as well as a lower estimated glomerular filtration rate and higher age, were significant risk factors for LA. CYA is known for its adverse LA effects, but it was not a significant risk factor for LA in patients undergoing maintenance phase kidney transplantation.

• Authors: N Ichimaru, K Yamanaka, T Kato, Y Kakuta, T Abe, R Imamura, N Nonomura, J-Y Kaimori, S Takahara
• Journal: Transplantation proceedings (Transplant Proc) Vol. 47 Issue 3 Pg. 672-4 (Apr 2015) ISSN: 1873-2623 [Electronic] United States
• PMID: 25891708 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Immunosuppressive Agents
• Lipids
• Ribonucleosides
• mizoribine
• Cyclosporine
• Everolimus
• Mycophenolic Acid
• Azathioprine
• Tacrolimus

Topics

• Adrenal Cortex Hormones (adverse effects, blood)
• Adult
• Aged
• Aged, 80 and over
• Azathioprine (adverse effects, blood)
• Cyclosporine (adverse effects, blood)
• Dyslipidemias (epidemiology, etiology)
• Everolimus (adverse effects, blood)
• Female
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (blood, therapeutic use)
• Immunosuppressive Agents (adverse effects, blood)
• Kidney Transplantation (adverse effects)
• Lipids (blood)
• Male
• Middle Aged
• Mycophenolic Acid (adverse effects, analogs & derivatives, blood)
• Ribonucleosides (adverse effects, blood)
• Risk Factors
• Tacrolimus (adverse effects, blood)