Abstract | OBJECTIVE: PATIENTS: A total of 569 NAFLD subjects underwent 75-g OGTT. The plasma glucose and insulin levels were analyzed periodically for three hours during the OGTT examinations. Impaired fasting glucose (IFG) was defined as a plasma glucose level of ≥100 mg/dL to <126 mg/dL. Diabetes was defined as a two-hour post-load plasma glucose level of ≥200 mg/dL. Elevated insulin resistance was defined as a homeostasis model assessment- insulin resistance (HOMA-IR) of ≥2.5. Insulin secretory insufficiency was defined as an insulinogenic index of <0.4. RESULTS: The prevalence of diabetes on the OGTT was 7.7% (44/569) among the NAFLD patients with an HbA1c level of ≤6.4%, FPG level of <126 mg/dL and no history of diabetes. A multivariate analysis showed that diabetes occurred more frequently when the subjects had IFG [odds ratio (OR) 5.13; 95% confidential interval (CI) 3.01-8.76; p<0.001] and an HbA1c level of 5.7-6.4% (OR 5.45; 95% CI 3.33-8.93; p<0.001). Of the NAFLD subjects with both IFG and an HbA1c level of 5.7-6.4%, 22.8% (28/123) exhibited a pattern of diabetes on OGTT. Regarding insulin dynamics, among the NAFLD subjects with both IFG and an HbA1c level of 5.7-6.4%, 25.2% (31/123) had elevated IR alone, 25.2% (31/123) had insulin secretory deficiency alone and 27.6% (34/123) had both elevated insulin resistance and insulin secretory deficiency. CONCLUSION:
NAFLD subjects with IFG and an HbA1c level of 5.7-6.4% should undergo OGTT in order to determine whether they have diabetes and/or abnormal insulin dynamics.
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Authors | Naoki Matsumoto, Yasuji Arase, Yusuke Kawamura, Miki Ohmoto-Sekine, Kazuhisa Amakawa, Kyoko Ogawa, Hiroshi Tsuji, Hsieh Shiun Dong, Shigeko Hara, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Kenji Ikeda, Hiromitsu Kumada, Tetsurou Kobayashi |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 54
Issue 8
Pg. 875-80
( 2015)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 25876566
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Insulin
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Topics |
- Aged
- Asian People
- Blood Glucose
- Diabetes Mellitus
(blood, diagnosis)
- Fasting
(blood)
- Female
- Glucose Tolerance Test
- Glycated Hemoglobin
- Humans
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Japan
(epidemiology)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(blood)
- Prediabetic State
(diagnosis)
- Prevalence
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