Clinical manifestations of patients with CASPR2 antibodies.

Abstract

Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.

• Authors: Jun-Sang Sunwoo, Soon-Tae Lee, Jung-Ick Byun, Jangsup Moon, Jung-Won Shin, Da-Eun Jeong, Gun-Hee Lee, Seong Ho Jeong, Yong-Won Shin, Keun-Hwa Jung, Doo Young Lee, Daejong Jeon, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 281 Pg. 17-22 (Apr 15 2015) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 25867463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• CNTNAP2 protein, human
• Membrane Proteins
• Nerve Tissue Proteins

Topics

• Adult
• Aged
• Autoantibodies (blood)
• Autoimmune Diseases of the Nervous System (blood, diagnosis, immunology)
• Autoimmunity (physiology)
• Child
• Epilepsy (blood, diagnosis, immunology)
• Female
• Follow-Up Studies
• HEK293 Cells
• Humans
• Male
• Membrane Proteins (blood)
• Middle Aged
• Nerve Tissue Proteins (blood)