The present study was conducted to evaluate the
analgesic, anti-inflammatory and
antipyretic activities of Thymus serphyllum Linn. in mice. Anti-inflammatory activity was evaluated by
carrageenan and egg
albumin induced paw
edema in mice, while
analgesic activity was assessed using
formalin induced paw licking and
acetic acid induced abdominal writhing in mice. For determination of
antipyretic activity,
pyrexia was induced by
subcutaneous injection of 20% yeast. All the extracts produced significant anti-inflammatory effect however,
ether extract produced maximum effect 34% inhibition (p < 0.001) against
carrageenan and 22% (p < 0.01) inhibition against egg
albumin induced paw
edema in mice at the end of 3 h.
Ether extract produced prominent
analgesic effect 77% (p < 0.001) inhibition in
acetic acid induced abdominal writhing and 59% inhibition in
formalin induced paw licking model in mice, respectively.
Ether extract also demonstrated significant (p < 0.001)
antipyretic activity against yeast induced
pyrexia. The plant showed no sign of toxicity up to the dose of 2000 mg/kg in mice. This study supports the use of Thymus serphyllum in
traditional medicine for
inflammation accompanied by
pain and
fever.