Abstract | PURPOSE: MATERIALS AND METHODS: A retrospective review of the medical records from the Department of Otolaryngology at Yonsei University College of Medicine was conducted from January 1994 to December 2009. A total of 49 patients underwent laryngopharyngectomy with thyroidectomy as a primary treatment of hypopharyngeal cancer. RESULTS: The incidence of thyroid gland involvement was 10.2%. The most common route of invasion was direct extension through the thyroid cartilage. Thyroid cartilage invasion (p=0.034) was the most significant factor associated with thyroid invasion. Disease-specific survival at 5 years was lower in patients with than without thyroid gland invasion (26.7% vs. 55.2%, respectively; p=0.032). Disease-free survival at 5 years was also lower in patients with than without thyroid gland invasion (20.0% vs. 52.1%, respectively; p=0.024). CONCLUSION: Ipsilateral thyroidectomy in combination with total laryngopharyngectomy is indicated when invasion of the thyroid cartilage is suspected in patients with hypopharyngeal cancer.
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Authors | Jae Won Chang, Yoon Woo Koh, Woong Youn Chung, Soon Won Hong, Eun Chang Choi |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 56
Issue 3
Pg. 812-8
(May 2015)
ISSN: 1976-2437 [Electronic] Korea (South) |
PMID | 25837190
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(epidemiology, pathology, surgery)
- Disease-Free Survival
- Female
- Humans
- Hypopharyngeal Neoplasms
(epidemiology, pathology, surgery)
- Incidence
- Laryngectomy
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasms, Second Primary
(epidemiology, pathology, surgery)
- Pharyngectomy
- Predictive Value of Tests
- Prevalence
- Republic of Korea
(epidemiology)
- Retrospective Studies
- Thyroid Gland
(pathology, surgery)
- Thyroid Neoplasms
(epidemiology, secondary)
- Thyroidectomy
(methods)
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