Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

Abstract

Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.

• Authors: Hye-Sook Seo, Jong-Kyu Woo, Yong Cheol Shin, Seong-Gyu Ko
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 12 Issue 1 Pg. 800-18 (Jul 2015) ISSN: 1791-3004 [Electronic] Greece
• PMID: 25778982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anticarcinogenic Agents
• Biomarkers, Tumor
• Neoplasm Proteins
• Nicotinic Acids
• Retinoid X Receptors
• Tetrahydronaphthalenes
• Bexarotene
• LG 100268

Topics

• Anticarcinogenic Agents (administration & dosage)
• Bexarotene
• Biomarkers, Tumor (genetics)
• Breast (metabolism)
• Breast Neoplasms (drug therapy, genetics, pathology)
• Cell Proliferation (genetics)
• Epithelial Cells (drug effects)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• MCF-7 Cells
• Microarray Analysis
• Neoplasm Proteins (biosynthesis, genetics)
• Nicotinic Acids (administration & dosage)
• Retinoid X Receptors (agonists, genetics)
• Tetrahydronaphthalenes (administration & dosage)