Abstract | BACKGROUND: HYPOTHESIS/OBJECTIVES: ANIMALS: Three client-owned dogs. RESULTS: The dogs exhibited rapid onset of papules, pustules and crusts at the site of application of the flea control product. In two dogs, the lesions became generalized, while the third exhibited a localized phenotype. Both dogs with generalized lesions required immunosuppressive treatment; one achieved remission after 1 year of treatment and one was euthanized due to adverse effects of glucocorticoids. The dog with a localized phenotype was treated with topical glucocorticoids exclusively and achieved remission after 10 months. Histology revealed subcorneal pustular dermatitis, with acantholysis of keratinocytes and focal to multifocal full-thickness epidermal necrosis. These features are similar to those previously reported for pesticide-triggered and spontaneous PF. Tissue-bound IgG was detected in two of three dogs, and autoantibodies targeting canine desmocollin-1 were identified in the serum of the one dog from which a sample was available. CONCLUSIONS AND CLINICAL IMPORTANCE:
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Authors | Petra Bizikova, Karen A Moriello, Keith E Linder, Leslie Sauber |
Journal | Veterinary dermatology
(Vet Dermatol)
Vol. 26
Issue 3
Pg. 206-8, e45-6
(Jun 2015)
ISSN: 1365-3164 [Electronic] England |
PMID | 25758668
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 ESVD and ACVD. |
Chemical References |
- Drug Combinations
- Guanidines
- Neonicotinoids
- Nitro Compounds
- Pesticides
- Pyridines
- dinotefuran
- pyriproxyfen
- Permethrin
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Topics |
- Animals
- Dog Diseases
(chemically induced, pathology)
- Dogs
- Drug Combinations
- Guanidines
(adverse effects)
- Male
- Neonicotinoids
- Nitro Compounds
(adverse effects)
- Pemphigus
(chemically induced, pathology, veterinary)
- Permethrin
(adverse effects)
- Pesticides
(adverse effects)
- Pyridines
(adverse effects)
- Skin
(drug effects, pathology)
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