BMI status influences the response of insulin sensitivity to diacylglycerol oil in Chinese type 2 diabetic patients.

Abstract

Present study was a post-hoc analysis and aimed to examine the influence of adiposity status on the response of insulin sensitivity to diacylglycerol (DAG) oil in type 2 diabetic patients. A total of 127 type 2 diabetic patients were recruited into a randomized double-blind controlled parallel trial in Hangzhou, China. Subjects were allocated to consume the same amount (25 mL/d) of DAG (n=66) or triacylglycerol (TAG) oil (n=61) with similar fatty acid compositions for 120 days. Marginally significant interaction was observed between BMI status (overweight versus normal weight) and test oils for fasting insulin (p-interaction=0.046) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (p-interaction=0.059). For normal weight subjects (BMI<=25), DAG group showed significant decrease of fasting insulin (-2.0, 95% CI: -3.90, -0.10; p=0.036) and HOMA-IR (-0.69, 95% CI: -1.36, -0.03; p=0.015), but not in the TAG group. No significant change of either trait in DAG or TAG group was observed for overweight subjects (BMI>25). In summary, the effect of DAG oil on insulin sensitivity in type 2 diabetic patients is influenced by the baseline BMI status. Type 2 diabetic patients may benefit from DAG oil in terms of insulin sensitivity improvement, however only when they are in normal body weight range.

• Authors: Ju-Sheng Zheng, Ling Wang, Mei Lin, Hong Yang, Duo Li
• Journal: Asia Pacific journal of clinical nutrition (Asia Pac J Clin Nutr) Vol. 24 Issue 1 Pg. 65-72 ( 2015) ISSN: 0964-7058 [Print] Australia
• PMID: 25740744 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats, Unsaturated
• Diglycerides
• Fatty Acids
• Triglycerides

Topics

• Adult
• Aged
• Body Mass Index
• China
• Diabetes Mellitus, Type 2 (complications, drug therapy, physiopathology)
• Dietary Fats, Unsaturated (administration & dosage)
• Diglycerides (administration & dosage)
• Double-Blind Method
• Fatty Acids (administration & dosage)
• Female
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Obesity (complications)
• Overweight (complications)
• Triglycerides (administration & dosage)