The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells.

Abstract

We investigated the possible presence of functional human chorionic gonadotropin (hCG)/luteinizing hormone (LH) receptors in β-cells of pancreas, using a combination of techniques on hCG/LH receptor knockout mice, immortalized rat insulinoma cells, and human pancreatic islets. The results showed the presence of receptors and their activation resulted in a dose-dependent increase in glucose-induced release of insulin. These findings place hCG and LH among the regulators of insulin release with potential implications for insulin-level changes during the periods of altered hCG and LH secretion.

• Authors: Jai Parkash, Zhenmin Lei, C V Rao
• Journal: Reproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 22 Issue 8 Pg. 1000-7 (Aug 2015) ISSN: 1933-7205 [Electronic] United States
• PMID: 25670721 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2015.

Chemical References

• Chorionic Gonadotropin
• Insulin
• Receptors, LH
• Glucose

Topics

• Animals
• Cadaver
• Cell Line, Tumor
• Chorionic Gonadotropin (pharmacology)
• Dose-Response Relationship, Drug
• Female
• Glucose (metabolism)
• Insulin (metabolism)
• Insulin Secretion
• Insulin-Secreting Cells (drug effects, metabolism)
• Mice, Knockout
• Rats
• Receptors, LH (agonists, deficiency, genetics, metabolism)
• Tissue Culture Techniques