Long-term effects of intratympanic methylprednisolone perfusion treatment on intractable Ménière's disease.

Abstract

OBJECTIVE:

This study aimed to investigate the long-term efficacy of intratympanic methylprednisolone perfusion treatment for intractable Ménière's disease.

METHODS:

A retrospective analysis of 17 intractable Ménière's disease patients treated with intratympanic methylprednisolone perfusion was performed. Treatment efficacy was evaluated according to the American Academy of Otolaryngology-Head and Neck Surgery criteria. Short and long-term control or improvement rates were calculated after 6 and 24 months, respectively.

RESULTS:

Sixteen patients were followed for more than two years. Short- and long-term vertigo control rates were 94 per cent and 81 per cent, respectively; short- and long-term functional activity improvements were 94 per cent and 88 per cent, respectively. The pure tone average was 53 ± 14 dB before treatment, and 50 ± 16 dB at 6 months and 52 ± 20 dB at 24 months after intratympanic methylprednisolone perfusion. Tinnitus was controlled or improved in five patients over the two-year follow-up period.

CONCLUSION:

Intratympanic methylprednisolone perfusion can effectively control vertigo and improve functional activity in intractable Ménière's disease patients with good hearing preservation. It may therefore be a viable alternative treatment for intractable Ménière's disease.

• Authors: W She, L Lv, X Du, H Li, Y Dai, L Lu, X Ma, F Chen
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 129 Issue 3 Pg. 232-7 (Mar 2015) ISSN: 1748-5460 [Electronic] England
• PMID: 25655232 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Methylprednisolone

Topics

• Adult
• Audiometry, Pure-Tone (methods)
• Female
• Glucocorticoids (administration & dosage, adverse effects)
• Humans
• Injection, Intratympanic
• Male
• Meniere Disease (drug therapy, physiopathology)
• Methylprednisolone (administration & dosage, adverse effects)
• Middle Aged
• Retrospective Studies
• Treatment Outcome