Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.

Abstract

AIM:

This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

MATERIALS AND METHODS:

The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.

RESULTS:

Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

CONCLUSIONS:

The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.

• Authors: Muyesser Sayki Arslan, Oya Topaloglu, Bekir Ucan, Melia Karakose, Basak Karbek, Esra Tutal, Mustafa Caliskan, Zeynep Ginis, Erman Cakal, Mustafa Sahin, Mustafa Ozbek, Tuncay Delibasi
• Journal: TheScientificWorldJournal (ScientificWorldJournal) Vol. 2015 Pg. 239815 ( 2015) ISSN: 1537-744X [Electronic] United States
• PMID: 25654127 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Thyroid Hormones
• Vitamin D
• Thyrotropin

Topics

• Adult
• Autoantibodies (immunology)
• Case-Control Studies
• Euthyroid Sick Syndromes (etiology)
• Female
• Humans
• Male
• Syndrome
• Thyroid Gland (immunology)
• Thyroid Hormones (blood)
• Thyroiditis, Autoimmune (etiology)
• Thyrotropin (blood)
• Vitamin D (blood)
• Vitamin D Deficiency (complications)