Abstract | BACKGROUND: METHODS: Samples from 128 patients with IPD were collected at the time of first positive blood culture and analysed using an in-house sMR assay. Clinical data were retrieved from patient files. The main outcome investigated was in-hospital mortality. RESULTS: The median sMR concentration in the entire group of patients was 0.77 mg/L. There was a significant difference in sMR concentration between patients below (n = 92, sMR = 0.82 mg/L) or above (n = 36, sMR = 0.73 mg/L) the age of 75 (p < 0.001). In the entire group there was a significant difference in sMR concentrations between survivors (n = 107, sMR = 0.72 mg/L) and non-survivors (n = 21, sMR = 1.38 mg/L), but for patients 75 years or older this difference was not statistically significant. For prediction of survival sMR seemed most promising (area under the receiver operating characteristic curve (AUC) = 0.79) compared with sCD163 (AUC = 0.70) and CRP (AUC = 0.73). In patients 75 years or older the AUC was lower for all three markers (sMR = 0.56, sCD163 = 0.38, CRP = 0.66). CONCLUSIONS: The results of this study designate sMR as a potential new biomarker in infectious disease. Additionally, it emphasizes the importance of research into macrophage malfunction in elderly patients.
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Authors | Sidsel Rødgaard-Hansen, Aisha Rafique, Nina Weis, Christian Wejse, Henrik Nielsen, Svend Stenvang Pedersen, Holger Jon Møller, Gitte Kronborg |
Journal | Infectious diseases (London, England)
(Infect Dis (Lond))
Vol. 47
Issue 4
Pg. 203-8
(Apr 2015)
ISSN: 2374-4243 [Electronic] England |
PMID | 25650730
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Lectins, C-Type
- Mannose Receptor
- Mannose-Binding Lectins
- Receptors, Cell Surface
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bacteremia
(blood, epidemiology, mortality)
- Biomarkers
(blood)
- Comorbidity
- Female
- Humans
- Lectins, C-Type
(blood)
- Male
- Mannose Receptor
- Mannose-Binding Lectins
(blood)
- Middle Aged
- Pneumococcal Infections
(blood, epidemiology, mortality)
- Prognosis
- Receptors, Cell Surface
(blood)
- Young Adult
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