Abstract | BACKGROUND: METHODS: An observational study of 901 stem cell transplant recipients was conducted at Northwestern Memorial Hospital to identify the incidence, risk factors and outcomes for HSCT recipients who develop infection(s) with multiple bacterial or fungal organisms. RESULTS: Among 901 HSCT recipients reviewed (675 autografts and 226 allografts), 237 patients (27%) had microbiologically documented microorganisms isolated, including 179 patients (76%) with monomicrobial infection and 59 patients (24%) with multiple microorganisms, of which 34 (14%) were classified as PI, and 25 (10%) as multiple distinct episodes of infection. CONCLUSION: The results show co-infection with multiple organisms during HSCT is relatively rare; however, these patients are at an increased risk for the development of acute graft-versus-host disease, delayed engraftment, and overall mortality.
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Authors | S Trifilio, Z Zhou, J L Fong, A Zomas, D Liu, C Zhao, J Zhang, J Mehta |
Journal | Transplant infectious disease : an official journal of the Transplantation Society
(Transpl Infect Dis)
Vol. 17
Issue 2
Pg. 267-74
(Apr 2015)
ISSN: 1399-3062 [Electronic] Denmark |
PMID | 25648349
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Bacterial Infections
(epidemiology, etiology, immunology)
- Cohort Studies
- Coinfection
(epidemiology, etiology, immunology)
- Female
- Graft vs Host Disease
(prevention & control)
- Hematologic Neoplasms
(therapy)
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunocompromised Host
- Immunosuppressive Agents
(adverse effects)
- Incidence
- Male
- Middle Aged
- Mycoses
(epidemiology, etiology, immunology)
- Retrospective Studies
- Risk Factors
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